Chemical Induction

Research in chemical induction [5] seeks to identify the compound or compounds responsible for differentiation [6] in a developing embryo. Soren Lovtrup [7] compared the search for these compounds to the search for the philosopher?s stone. It was based on the assumption that the differentiating agents have to be chemical substances either within cells or in the extracellular matrix. However, despite numerous efforts to understand them, the nature of these substances remained largely a mystery from the 1930s until the 1980s, when the new era of molecular induction [5] based on molecular genetics provided a new perspective. During the period of emphasis on chemical induction [5], a variety of different experiments were conducted aimed at discovering the chemical nature of the inducer. In some experiments, the organizer [8] region was killed by heat to assess the inducing ability of a dead organizer [8]. Other experiments used natural and synthetic compounds to attempt induction [5]. Although none of these experiments identified a chemical inducer with any certainty, they did discover many related properties of the developing embryo.